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IP3R S-glutathionylation may represent a fundamental mechanism for regulating IP3R activity during physiological redox signaling during pathological oxidative stress [86]

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Sildenafil could ameliorate neuropathic pain symptoms in patients with diabetic peripheral neuropathy [143] and showed an antinociceptive effect in Sprague–Dawley male rats’ neuropathic pain models [144]

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