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However, there are examples of patients that present with 5-oxoprolinuria who have normal circulating glutathione concentrations despite increased 5-oxoproline levels (Calpena et al., 2013)

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Type 2 Diabetes A study compared individuals with Diabetes Mellitus, Impaired Glucose Tolerance, and normal controls: “The mean levels of GSH in subjects with DM were significantly reduced compared with IGT or normal subjects… we came to the conclusion that GSH deficiency was of great significance in the pathogenesis of Diabetes Mellitus.” Autism An 8 week open label trial using liposomal glutathione showed “Recent evidence shows that children diagnosed with an ASD have lower levels of plasma reduced glutathione (generally 20–40% lower) than typically developing children and their levels of oxidized glutathione are higher than typically developing children… oral and transdermal glutathione supplementation may have some benefit in improving some of the transsulfuration metabolites.” Rheumatoid Arthritis A small study of 58 rheumatic patients “Rheumatoid arthritis was associated with significant depletion (ca