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Although the low absorption of SBA-15 in non-inflamed gut tissues could limit its overall efficacy, the inflamed intestinal barrier enhanced particle uptake, supporting the potential of Ac2-26 as a minimally invasive and cost-effective IBD therapy

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This review synthesizes insights into metal transporters to advance our understanding of their roles in maintaining systemic and brain Mn homeostasis under healthy conditions and their contribution to Mn dysregulation in disease states, particularly neurological disorders

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