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71 However, during periods of fluctuating progesterone levels, eg, in progesterone-withdrawal models, GABA A -receptor composition shifts by sharply increasing the expression of the α 4 and δ subunits in the CA1 subregion of the hippocampus, 72,73 while at the same time reducing the expression of the α 1 subunit

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Administration technique and dosing may vary depending on individual patient needs