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10.3389/fphys.2014.00024 47 MiroshnychenkoO.ChangW

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Additionally, in a mouse model involving the adoptive transfer of microbiota-specific T cells, butyrate-stimulated IL-10 secretion by Th1 and Th17 cells reduced colitis severity ( In vitro , butyrate and propionate also suppress LPS-induced maturation of human monocyte-derived dendritic cells, leading to reduced IL-12 secretion and diminished CD8 + T cell activation (Nastasi et al., 2017)