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5.4 Use in Women of Childbearing Potential Because of the risk to the fetus of decreased IQ, neurodevelopmental disorders, and major congenital malformations (including neural tube defects), which may occur very early in pregnancy, valproate should not be administered to a woman of childbearing potential unless other medications have failed to provide adequate symptom control or are otherwise unacceptable

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Keywords: Fibroblast Activation, Basement Membrane, Laminin, Collagen IV, Fibronectin, Epigenetic Modification Graphical Abstract: Introduction Human fibrotic disease effects a large population of patients and constitutes a substantial public health burden worldwide (1, 2)