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The field needs validated, in vivo–compatible flux sensors (O 2 ·−, H 2 O 2 , NO/ONOO − ) targeted to matrix/IMS, ER lumen, peroxisomes, plasma-membrane microdomains and nucleus, each with built-in specificity controls and reporting standards (matrix, oxygen tension, ΔΨm, pH) to disambiguate signalling pulses from damage plateaus

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Alli orlistat – European Medicines Agency.