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Subsequently, PIP3 activates PDK1, which in turn phosphorylates a tyrosine of survival protein kinase B (Akt kinase)
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Upon PAMP (e.g., the bacterial glycolipid lipopolysaccharide (LPS)) or DAMP (e.g., HMGB1, S100 proteins) recognition, intracellular signaling cascades are activated through myeloid differentiation primary response 88 (MyD88)- and TIR-domain-containing adapter inducing interferon (TRIF)-dependent pathways, leading to the activation of NF-κB, MAPK, and interferon regulatory factors (IRFs)