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Introduction Cognitive decline may occur for a variety of reasons, including the accumulation of senescent cells, 1 excessive oxidative stress, 2 mitochondrial dysfunction, 3 loss of apoptosis, 4 environmental toxins 5,6 depletion of stem cells, 7 telomere shortening, 8 inefficient cell communication, 9 epigenetic alterations 10 and neuroinflammation